Amy Herr

Assistant Professor, Bioengineering Faculty Scientist, Physical Biosciences Division, LBNL Core Member, UCB/UCSF Graduate Group in Bioengineering 308B Stanley Hall mailcode: 1762 (510) 666-3396 fax: (510) 642-5835 This e-mail address is being protected from spambots. You need JavaScript enabled to view it http://herrlab.berkeley.edu Membership effective July 2007

Research Interests

Use of scale-dependent phenomena to develop new tools for quantifying biomolecules in complex biological fluids.

Research Summary

A major focus of our lab is engineering innovation for analysis of complex biological systems -- as is required to address questions important to both fundamental biological systems and applied clinical research. We employ a combination of approaches drawn from chemical engineering, mechanical engineering, and electrical engineering with strong foundations in biology, materials science, and analytical chemistry.  In essence, we strive to advance the "mathematization" of biology & medicine.

Research includes design and development of instrumentation that exploits scale-dependent physics and chemistry. Our work accelerates development of bioanalytical methods, streamlines sample preparation strategies, improves biomarker validation studies, and advances clinical diagnostics.

Selected Publications

S Tia & AE Herr. On-chip Technologies for Multi-dimensional Separations. Lab Chip, 2009, accepted.

N Srivastava, JS Brennan, RF Renzi, M Wu, SS Branda, AK Singh, AE Herr. Fully integrated microfluidic platform enabling automated phosphoprofiling of macrophage response. Analytical Chemistry, 2009, 81(9), 3261-9.

CA Ramseier, JS Kinney, AE Herr, T Braun, JV Sugai, CA Shelburne, LA Rayburn, HM Tran, AK Singh, WV Giannobile. Identification of pathogen and host-response markers correlated with periodontal disease. J Periodontol, 2009, 80(3), 436-46.

C Hou & AE Herr. Clinically-relevant Advances in On-chip Affinity-based Electrophoresis and Electrochromatography. Electrophoresis, 2008, 29(16), 3306-19.

CT Lo¹, DJ Throckmorton¹, AK Singh & AE Herr. Photopolymerized Diffusion-Defined Polyacrylamide Gradient Gels for On-chip Protein Sizing. Lab Chip, 2008, 8(8), 1273-9. ¹equal contributors

AE Herr, AV Hatch, DJ Throckmorton, HM Tran, JS Brennan, WV Giannobile, AK Singh. Microfluidic Immunoassays as Rapid Saliva-based Clinical Diagnostics. Proc Natl Acad Sci USA, 2007, 104(13), 5268-5273.

AV Hatch, AE Herr, DJ Throckmorton, JS Brennan, and AK Singh. Integrated Preconcentration SDS-PAGE of Proteins in Microchips Using Photopatterned Cross-Linked Polyacrylamide Gels. Anal Chem, 2006, 78(14), 4976 - 4984.

VC Rucker, KL Havenstrite, BA Simmons, SM Sickafoose, AE Herr, R Shediac. Functional Antibody Immobilization on 3-Dimensional Polymeric Surfaces Generated by Reactive Ion Etching. Langmuir, 2005, 21(17), 7621-7625.

VC Rucker, KL Havenstrite, AE Herr. Antibody Microarrays for Native Toxin Detection. Anal Biochem, 2005, 339(2), 262-270.

AE Herr, DJ Throckmorton, AA Davenport, AK Singh. On-chip Native Gel Electrophoresis-Based Immunoassays for Tetanus Antibody and Toxin. Anal Chem, 2005, 77(2), 585-590.

AE Herr, AK Singh. Photopolymerized cross-linked polyacrylamide gels for on-chip protein sizing. Anal Chem, 2004, 76(16), 4727-33.

AE Herr, JI Molho, KA Drouvalakis, JC Mikkelsen, PJ Utz, JG Santiago, TW Kenny. On-Chip Coupling of Isoelectric Focusing and Free Solution Electrophoresis for Multi-Dimensional Separations. Anal Chem, 2003, 75(5), 1180-1187.

F Raisi, P Belgrader, DA Borkholder, AE Herr, GJ Kintz, F Pourhamadi, MT Taylor, MA Northrup. Microchip Isoelectric Focusing Using a Miniature Scanning Detection System. Electrophoresis, 2001, 22(11), 2291-2295.

JI Molho, AE Herr, BP Mosier, JG Santiago, TW Kenny, RA Brennen, GB Gordon, B Mohammadi. Optimization of Turn Geometries for Microchip Electrophoresis. Anal Chem, 2001, 73(6),1350-1360.

AE Herr, JI Molho, JG Santiago, MG Mungal, TW Kenny, MG Garguilo. Electroosmotic Capillary Flow with Nonuniform Zeta Potential. Anal Chem, 2000, 72(5), 1053-1057.