Irina Conboy

Assistant Professor, Bioengineering Core Member, UCB/UCSF Graduate Group in Bioengineering B108B Stanley Hall mailcode: 1762 (510) 666-2792 fax: (510) 642-5835 This e-mail address is being protected from spambots. You need JavaScript enabled to view it Membership effective July 2005

Research Interests

Research Summary

In their sum, the interconnected research venues pursued in my lab help to understand how the process of tissue repair is controlled, why the injured tissues are not productively repaired as we age and what approaches restore the regenerative potential both to the aged organ stem cells and to embryonic stem cell prpgeny exposed to the aged organ environments. Currently, we use the injury-regeneration of skeletal muscle as our experimental system, but hope to identify fundamental mechanisms of aging within stem cell niches, that apply to a variety of organs and tissues.

Selected Publications

    I. Conboy, and T. Rando. The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis. 2002. Developmental Cell, 3, 397-409.
    I. Conboy, M.J. Conboy, G.M. Smythe, and T. Rando. Notch-mediated restoration of regenerative potential to aged muscle. 2003. Science, 302, 1575-1577.
    Sherwood RI, Christensen JL, Conboy IM, Conboy MJ, Rando TA, Weissman IL, Wagers AJ. Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle. 2004; Cell, 119:543-554.
    I. Conboy, M. Conboy, A. Wagers, E. Girma, I. Weissman and T. Rando. Rejuvenation of aged progenitor cells by young systemic milieu. 2005, Nature, 433:760-764.
    Wagers AJ, and Conboy I.M. Cellular and molecular signatures of muscle regeneration. 2005, Cell,122,1-9.
    EdeJ. Pardo, M. Hoang and I.M. Conboy. Geometric control of myogenic cell fate. 2006, International Journal of Nanomedicine.1(2):203-212.
    M.E. Carlson and I.M. Conboy. Interaction between aged niche and human embryonic stem cells. 2007. Aging Cell, (3):371-82.We received a congratulatory email from CIRM senior officer on this manuscript.
    M. E. Carlson, M.S. O’Connor, M. Hsu, and I. M. Conboy. Notch Signaling Pathway and Tissue Engineering, 2007. Frontiers in Bioscience, 12:5143-56
    I.M. Conboy, M.H. Barcellos-Hoff, D. Schaffer, S. Li. Methods for derivation, culture and characterization of adult stem cells. 2007, invited book, Methods in Molecular Biology.
    M. Carlson and I.M. Conboy. Regulating Notch pathway in embryonic, adult, old and cancer stem cells. 2007. Current Opinion in Pharmacology, (3):303-9