Mohammad Mofrad

Assistant Professor, Bioengineering Core Member, UCB/UCSF Graduate Group in Bioengineering 208A Stanley Hall mailcode: 1762 (510) 643-8165 fax: (510) 642-5835 This e-mail address is being protected from spambots. You need JavaScript enabled to view it http://biomechanics.berkeley.edu Membership effective July 2005

Research Interests

The research in Mofrad Lab (Molecular Cell Biomechanics Laboratory) is focused around two main goals:

(1) To understand the principles underlying cellular mechanics, rheology, and mechanotransduction,

(2) To understand the multiscale biomechanical processes underlying cardiovascular tissue mechanotransduction involved in diseases like aortic valve calcification and arterial atherosclerosis.

Research Summary

The research in Mofrad Lab (Molecular Cell Biomechanics Laboratory) is focused around two main goals:

(1) To understand the principles underlying cellular mechanics, rheology, and mechanotransduction,

(2) To understand the multiscale biomechanical processes underlying cardiovascular tissue mechanotransduction involved in diseases like aortic valve calcification and arterial atherosclerosis.

Selected Publications

Molecular Cell Biomechanics & Mechanotransduction
Karcher H, Lammerding J, Huang H, Lee RT, Kamm RD, Kaazempur Mofrad MR. A three-dimensional viscoelastic model for cell deformation with experimental verification. Biophysical J. 2003 Nov;85(5):3336-49.

Kolahi KS, Mofrad MR. Molecular mechanics of filamin's rod domain. Biophysical Journal 2008 Feb 1;94(3):1075-83.
 
Lee SE, Chunsrivirot S, Kamm RD, Mofrad MR. Molecular Dynamics Study of Talin-Vinculin Binding. Biophys J. 2008 Aug. 15. 

Wolf CB, Mofrad MR. On the Octagonal Structure of the Nuclear Pore Complex: Insights from Coarse-Grained Models. Biophysical Journal. 2008 Aug. 15 [Cover Story]

Chandran PL, Mofrad MRK. Rods-on-string idealization captures semiflexible filament dynamics, PHYSICAL REVIEW E 79, 011906 2009

Chandran PL, Wolf CB, Mofrad MRK. Band-like Stress Fiber Propagation in a Continuum and Implications for Myosin Contractile Stresses


Cardiovascular Tissue Biomechanics & Mechanotransduction

Weinberg EJ, Kaazempur Mofrad MR. Transient, three-dimensional, multiscale simulations of the human aortic valve. Cardiovascular Eng. 2007 Dec;7(4):140-55.

Weinberg EJ, Kaazempur Mofrad MR. A Multiscale Computational Comparison of the Bicuspid and Tricuspid Aortic Valves in Relation to Calcific Aortic Stenosis. Journal of Biomechanics, 2008.

Weinberg EJ, Schoen FJ, Kaazempur Mofrad MR. A computational model of aging and calcification in the aortic heart valve, PLOS ONE, To appear, 2009
 
Books:
    Mofrad MRK and Kamm RD (Eds.) "Cytoskeletal Mechanics: Models and Measurements", Cambridge University Press, 2006.

  Mofrad MRK and Kamm RD (Eds.) "Cellular Mechanotransduction: Diverse Perspectives from Molecules to Tissues", Cambridge University Press, May 2009.

   De S, Guilak F, Mofrad MRK (Eds.) ,"Computational Methods in Biomechanics", Springer-Verlag, To appear in 2009.

Full list of publications can be found here: http://biomechanics.berkeley.edu