Randall Lee| | Professor of Clinical Medicine, Electrophysiology
Core Member, UCB/UCSF Graduate Group in Bioengineering MU 436 East
mailcode: Box 1354
(415) 476-5706
fax: (415) 476-6260
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Membership effective July 1999 |
Research Interests Tissue engineering directed at myocardial repair and conduction abnormalities. Research Summary Research interests involve utilizing tissue engineering and gene therapy techniques to determine the feasibility and potential adverse effects of molecular and cellular cardiomyoplasty. Myocardial reconstruction by cellular transplantation, gene therapy and structural matrix are being investigated. In addition, we are investigating whether skeletal muscle cells can form connections (gap junctions) with cardiac cells and propagate electrical activity and determining whether the overexpression of connexin 43 in skeletal cells form functional gap junctions and alter conduction. Selected Publications Lee RJ, Springer M, Blanco W, Shaw R, Ursell P, Blau H. VEGF gene delivery to the myocardium: deleterious
effects of unregulated overexpression (submitted)
Gallinghouse GJ, Sievers RE, Ursell PC, Lee RJ. Adenoviral Mediated Gene Expression Localized to the Cardiac
Conduction System: Effects on Electrophysiologic Properties. (submitted)
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