Sabrina Ronen| | Associate Professor, Radiology
Core Member, UCB/UCSF Graduate Group in Bioengineering UCSF Mission Bay, 1700 4th St., Suite 303
mailcode: 2532
415-514-4839
fax: 415-514-2550
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http://www.radiology.ucsf.edu/surbeck/programs/pi/ronen Membership effective July 2008 |
Research Interests The goal of research performed in my laboratory is to develop, validate and implement robust noninvasive magnetic resonance (MR)–based methodologies that can be used: (1) to detect oncogenic mutations that lead to onset and progression of cancer; and (2) to monitor response to traditional chemotherapies and novel molecular targeted therapies. Research Summary The goal of research performed in my laboratory is to develop, validate and implement robust noninvasive magnetic resonance (MR)–based methodologies that can be used: (1) to detect oncogenic mutations that lead to onset and progression of cancer; and (2) to monitor response to traditional chemotherapies and novel molecular targeted therapies. Our work focuses on preclinical cell and xenograft models and uses multinuclear 31P, 1H, 13C, hyperpolarized 13C and 19F MR spectroscopy (MRS) and MR imaging (MRI) as well as complementary biological, biochemical and molecular biological techniques. Our studies result in validated MR biomarkers of transformation and response to treatment that can be translated to patients in vivo.
Selected Publications
S.M. Ronen, E. Rushkin, H. Degani. Lipid metabolism in large T47D human breast cancer spheroids: 31P- and 13CNMR
studies of choline and ethanolamine uptake. Biochim. Biophys. Acta., 1992.
S.M. Ronen, F. DiStefano, C.L. McCoy, D. Robertson, T.A. Smith, N.M. Al-Saffar, J. Titley, D.C. Cunningham, J.R. Griffiths,
M.O. Leach, P.A. Clarke. Magnetic resonance detects metabolic changes associated with chemotherapy-induced
apoptosis. Br. J. Cancer, 1999.
Y.L. Chung, H. Troy, U. Banerji, L.E. Jackson, M.I. Walton, M. Stubbs, J.R. Griffiths, I.R. Judson, M.O. Leach, P. Workman,
S.M. Ronen. Magnetic resonance spectroscopic pharmacodynamic markers of the heat shock protein 90 inhibitor
17-allylamino,17-demethoxygeldanamycin (17AAG) in human colon cancer models. J. Natl. Cancer Inst., 2003.
M. Beloueche-Babari, L.E. Jackson, N.M. Al-Saffar, P. Workman, M.O. Leach, S.M. Ronen. Magnetic resonance
spectroscopy monitoring of mitogen-activated protein kinase signaling inhibition. Cancer Res., 2005.
M. Sankaranarayanapillai, W.P. Tong, D.S. Maxwell, A. Pal, J. Pang, W.G. Bornmann, J.G. Gelovani, S.M. Ronen.
Detection of histone deacetylase inhibition by noninvasive magnetic resonance spectroscopy. Mol. Cancer Ther., 2006.
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