Thomas Lang

Research Interests

Quantitative 3-D CT imaging of the musculoskeletal system.

Research Summary

Our research is focused on quantitative imaging of the musculoskeletal imaging in the assessment of skeletal fragility and osteoporosis. We have three overall research aims

1) Biomechanical modeling of bone from CT images to study bone strength as a function of age and drug treatment

2) Quantitative image analysis of the lower leg musculature gain insight into physical function and performance relat! ed to risk of falling

3) Imaging based integrative study of how age-related neurodegenerative processes affect the composition and function of musculoskeletal tissues

Selected Publications

Li W, Sode M, Saeed I, Lang T. Automated registration of hip and spine for longitudinal QCT studies: integration with 3D densitometric and structural analysis. Bone, Issue: 2. 38: 273-9, Feb/2006

Meta M, Lu Y, Keyak JH, Lang T. Young-elderly differences in bone density, geometry and strength indices depend on proximal femur sub-region: A cross sectional study in Caucasian-American women. Bone, Issue 1 39:152-158, July/2006

Lang T, LeBlanc A, Evans H, Lu Y. Geometric adaptation of the proximal femur to skeletal reloading after long-duration spaceflight J Bone and Miner Research, Issue 8 21:1224-30, Aug/2006

Sigurdsson G, Aspelund T, Chang MR, Jonsdottir B, Sigurdsson S, E! iriksdottir G, Gudmundsson A, Harris, TB, Gudnason V, Lang TF. Increas ing sex difference in bone strength in old age: the Age, Gene/Environment Susceptibility – Reykjavik Study (AGES-REYKJAVIK) Bone, Issue 3, 39: 644-51, Sept/2006

Cheng X,Li J, Lu Y, Keyak J, Lang T. Proximal femoral density and geometry measurements by quantitative computed tomography: association with hip fracture, Bone, Issue 1, 40: 169-74 Jan/2007.

Li W, Kezele I, Collins D, Zijdenbos A, Keyak J, Kornak J, Koyama A, Saeed I, LeBlanc A, Harris T, Lu Y, Lang T, Voxel-based modeling and quantification of the proximal femur using quantitative computed tomography, Bone 2007 Nov;41(5):888-95.

Lang T, Koyama A, Li C, Lu Y, Li J, Saeed I, Gazze E, Keyak J, Harris T and Cheng X, Pelvic body composition measurements by quantitative computed tomography: association with recent hip fracture, Bone. 2008 Apr;42(4):798-805.

Prevrhal S, Shepherd J, Faulkner K, Black D and Lang T, Comparison of DXA Hip Structural Analysis with volume! tric QCT, J Clin Densitometry 2008 Apr-Jun;11(2):232-6.