Daniel Fletcher

Daniel A. Fletcher

faculty photo

Purnendu Chatterjee Chair in Engineering Biological Systems and Chair, Bioengineering
Faculty Scientists, Physical Biosciences Division, LBNL;

608B Stanley Hall
Mailcode 1762
UC Berkeley

For more information, see: http://fletchlab.berkeley.edu/

Research Areas

Biomechanics, Biomedical Imaging & Instrumentation, Drug Delivery Systems & Pharmacogenomics, and Tissue Engineering & Regenerative Medicine

Research Interests

The Fletcher Lab develops diagnostic technologies and studies mechanical regulation of membrane and cytoskeleton organization in the context of cell motility, signaling, and host-pathogen interactions. We specialize in development of optical microscopy, force microscopy, and microfluidic technologies to understand fundamental organizational principles through both in vitro reconstitution and live cell experiments. Recent work includes investigating the mechano-biochemistry of branched actin network assembly with force microscopy, studying membrane deformation by protein crowding and oligomerization with model membranes, and reconstituting spindle scaling in encapsulated cytoplasmic extracts. The long-term goal of our work is to understand and harness spatial organization for therapeutic applications in cancer and infectious diseases.