Jennifer Doudna

Jennifer Doudna

Li Ka Shing Chancellor’s Chair in Biomedical and Health Sciences,
Howard Hughes Medical Institute Investigator,
Professor, Molecular & Cell Biology and Chemistry

708A Stanley Hall
Mailcode Mailcode 3220
UC Berkeley

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Research Areas

Biomaterials and Computational Biology, Bioinformatics, Genomics

Research Interests

Jennifer Doudna and her lab are researching the molecular basis for CRISPR-Cas genome protection and editing. CRISPR is a surgical tool for changing the code of life. In bacteria, CRISPR systems preserve invading genetic material and incorporate it into surveillance complexes to achieve adaptive immunity. Crystal structures of diverse Cas9 proteins reveal RNA-mediated conformational activation. Further, the Doudna lab is exploring translational control. The eukaryotic translation machinery is a critical control point for the induction of gene expression. Viruses by necessity hijack the translational equipment. One area of interest is HCV IRES which bypasses normal regulatory mechanisms to promote viral gene expression.