Bo Huang

Bo Huang

faculty photo

Professor, Department of Pharmaceutical Chemistry
Professor, Department of Biochemistry and Biophysics
Investigator, Chan Zuckerberg Biohub

Byers Hall 303A
Mailcode MC 2532

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Research Areas

Biomedical Imaging & Instrumentation, BioMEMS & Nanotechnology, and Systems & Synthetic Biology

Research Interests

Cellular processes are orchestrated by a large number of biomolecules in a spatially and temporally coordinated manner within a tiny volume. To uncover the underlying organizational principles and their functional relevance, we use microscopy visualization to systematically map the spatial localization, temporal dynamics and activity profiles of proteins and nucleic acids. For this purpose, we are developing super-resolution and light-sheet microscopy techniques for higher spatiotemporal resolution subcellular imaging and for tracking cells in intact animals. We are also developing fluorescent probes based on split proteins, nanobodies and CRISPR/Cas9 system to report localization, conformation and functional modification of proteins and nucleic acids. We are particularly interested in understanding the physical organization of the genome, the architecture of centrosome/cilium, and subcellular compartmentalization of signaling molecules.