Deepak Srivastava

Subject areas:

Research

Dr. Srivastava’s laboratory discovered genetic bases for cardiac septal and valve defects and revealed complex signaling, transcriptional, and translational networks that regulate progenitor cells to adopt a cardiac cell fate and subsequently fashion a functioning heart. He has leveraged this knowledge to understand disease mechanisms using induced pluripotent stem cells, leading to new therapeutic candidates for heart disease. His laboratory also used developmental gene networks to reprogram resident cardiac fibroblasts directly into cardiomyocyte-like cells for regenerative purposes in the setting of heart failure.