Associate Professor, Department of Physiology.
Investigator of Cardiovascular Research Institute and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF
Phone: 415-502-2873555 Mission Bay Blvd S, Rm 352V
The regenerative potential in the animal kingdom displays striking divergence across ontogeny and phylogeny. For example, heart regeneration is remarkably robust in adult zebrafish and newborn mice while very limited in adult mammals. This presents a particular problem for patients with a heart attack who suffer from loss of millions of heart muscle cells and life-threatening functional deterioration of the heart.
We use the heart as a model system and an entry point to study organ regeneration and repair in adult zebrafish, neonatal and adult mice, with an emphasis on the pathways that regulate resident stem cell activation and mature cell dedifferentiation/proliferation, and with innovative and integrated approaches in engineering, single cell analysis, advanced imaging microscopy and genome manipulation technology.