Associate Professor, Department of Biochemistry and Biophysics and Institute for Neurodegenerative Diseases, UCSF
Phone: 415-514-5545
675 Nelson Rising Lane, Room 311AUCSF
San Francisco, CA 94143
Subject areas:
Research
We develop and apply systems biology and synthetic biology approaches to understand cellular mechanisms of human diseases and uncover new therapeutic targets. Our discovery platform uses CRISPR-based functional genomics in human iPSC-derived neurons and glia. We generate systematic genetic interaction maps and genetic perturbation coupled to high-content imaging and single-cell RNA-Seq to elucidate cellular networks. One of our next engineering goals is to control gene expression in brain organoids with temporal, spatial and cell-type specificity.