Associate Professor, Department of Biochemistry and Biophysics and Institute for Neurodegenerative Diseases, UCSF
Phone: 415-514-5545675 Nelson Rising Lane, Room 311A
San Francisco, CA 94143
We develop and apply systems biology and synthetic biology approaches to understand cellular mechanisms of human diseases and uncover new therapeutic targets. Our discovery platform uses CRISPR-based functional genomics in human iPSC-derived neurons and glia. We generate systematic genetic interaction maps and genetic perturbation coupled to high-content imaging and single-cell RNA-Seq to elucidate cellular networks. One of our next engineering goals is to control gene expression in brain organoids with temporal, spatial and cell-type specificity.