Simon Little

Subject areas:

Research

In the Little lab we research the cortical and basal ganglia brain networks that cause movement and non – motor (incl. mood, motivation and sleep) symptoms in movement disorders such as Parkinson’s disease. We record brain signals using intracranial electrodes, sensing-enabled Deep Brain Stimulation (DBS) pacemakers and closed-loop DBS to investigate these networks, in addition to neurophysiological and machine learning analyses. We aim to better understand the circuits and signals driving these disabling symptoms, discover fundamental brain mechanisms and advance new personalized, responsive neuromodulation therapies.